The International Symposium ISyCatC IV will focus on the targeting of  cathepsin C, a protease that activates most of tissue-degrading proteases during inflammatory diseases such as COPD, cystic fibrosis, bronchiectasis, granulomatosis with polyangiitis, inflammatory bowel diseases or rheumatoid arthritis. Cathepsin C thus appears as a potential therapeutic target to impair protease-driven tissue degradation in chronic inflammatory diseases.

This symposium will bring together for the third time the world leading specialists from academic labs and industry, working on cathepsin C and its target enzymes.  It will associate biochemists studying the functionality of cathepsin C, cell biologists studying its maturation and tissue localization, chemists developing specific cathepsin C  inhibitors and clinicians studying the pathologies in  which cathepsin C is directly or indirectly involved.

SYMPOSIUM ORGANIZED BY

Chair: Dr. Brice Korkmaz (INSERM, Université de Tours, France)

Scientific Committee: Prof. Gilles Lalmanach (INSERM, Université de Tours, France), Dr Aurélien Montagu (Le Studium Loire Valley/France), Prof. Grazyna Kwapiszewska (Ludwig Boltzmann Institute for Lung Vascular Research, Austria), Prof. Joanna Cichy (Jagiellonian University, Poland), Prof. Artur Gieldon (University of Gdansk, Poland), Dr Marko Novinec (University of Ljubljana, Slovenia), Dr Makis Zoidakis (Academy of Athens, Greece), Prof. Sevil Korkmaz-Icöz (University Hospital Heidelberg, Germany), Prof. Patrick MacDonald (Université de Sherbrooke, Canada)

Organization Committee: Dr. Roxane Domain, Dr. Thibault Chazeirat, Anne-Sophie Venet Charles (INSERM, Université de Tours, France